Does cannabis interact with antidepressants or lithium?
Cannabis and antidepressants
Cannabis or marijuana can interact with tricyclic antidepressants (TCAs), such as amitriptyline, imipramine and dothiepin.
Both cannabis and TCAs can cause an abnormally fast heartbeat (tachycardia) and high blood pressure (hypertension). There’s also a risk of other side effects, such as confusion, restlessness, mood swings and hallucinations.
There’s a risk that using cannabis while you’re on any of these medicines could lead to problems such as tachycardia, even if you don’t already have a heart condition.
Little research has been done into the interaction of cannabis with other types of antidepressants, such as SSRIs.
Cannabis and lithium
Lithium is used to treat bipolar disorder, a condition where people can switch between depression and extreme excitement and agitation (mania).
There’s little evidence to suggest that people who use cannabis should normally not take lithium, but this hasn’t been properly researched.
Side effects of cannabis
It’s not clear how often cannabis itself can cause anxiety or depression, but research suggests this can happen.
It’s therefore recommended that if you’re anxious or depressed and you use cannabis regularly, you should try giving up and see if that helps.
Tachycardia, dizziness, anxiety, drowsiness, nausea and vomiting, difficulty sleeping and confusion are all possible side effects of cannabis.
These side effects can also be caused by certain antidepressants, so using cannabis at the same time can make them worse.
If you have any concerns about the medicines you’re taking, talk to your GP or pharmacist.
You can also phone NHS 111 or Talk to Frank, a friendly confidential drugs helpline, on 0300 123 6600.
- Antidepressant drugs
- Can I drink alcohol if I’m taking antidepressants?
- Medicines information
Page last reviewed: 27 March 2018
Next review due: 27 March 2021
Cannabis or marijuana is usually smoked and typically mixed with tobacco. It can interact with certain types of antidepressants, such as tricyclic antidepressants (TCAs), which share similar side effects.
Is It Safe To Smoke Weed While On Prozac?
As marijuana grows more accessible for patients suffering from depression and anxiety, it is expected that marijuana might have interactions with other drugs.
The cost of healthcare is on the rise, and as the disease becomes stronger, our ability to manage symptoms is becoming harder. Conditions have a funny of affecting more than just the person going through it but rather everyone else in their immediate ecosystem too.
People suffering from chronic diseases are continually looking for treatments that move beyond the traditional or mainstream. Marijuana has been used in traditional medicine for centuries, but due to its illicit status in the States, its actual medicinal values have not been explored thoroughly.
Since depression is a mood disorder, it affects the way a person’s entire being functions. Depression is known to come in phases.
It causes intense feelings of hopelessness and sadness to the person in the middle of the episode. Daily activities, including social commitments, school, work, appetite, and sleep, are all difficult to carry out.
Scientifically, there are three significant parts of the brain involved in the middle of a Major Depressive Disorder. The hippocampus, prefrontal cortex, and amygdala.
Scientists believe that it is cortisol levels in a person’s brain that trigger the beginning of a Major Depressive Disorder. Cortisol is considered to be the brain’s built-in alarm system. It is the primary stress hormone produced by our bodies.
A healthy brain can regulate these levels, but a mind going through a depressive episode has continuously elevated levels of Cortisol.
Most cells in the body are cortisol receptors, and due to the high level of this hormone, the body can start to alter or shut down bodily functions that get in its way.
These functions can be digestive, reproductive, or even immune in nature.
What is Prozac?
Prozac is one of the most commonly prescribed antidepressants on the market. To the point that it is one of the top 15 most widely consumed drugs in the United States of America. It is used to treat major depressive disorder, panic disorder, bulimia nervosa, and obsessive-compulsive disorder.
Also called fluoxetine, Prozac belongs to a class of drugs called selective serotonin reuptake inhibitor (SSRI). These drugs function by increasing the levels of serotonin in the brain.
Serotonin is called the ‘Feel good hormone” and is responsible for carrying messages between brain cells and regulate our wellbeing, appetite, good mood, and also the body clock.
Prozac blocks the absorption of the neurotransmitter serotonin. Serotonin levels if regulated, helps the brain cells transmit messages. This is how the depressive symptoms are restricted with the help of Prozac.
Side Effects of Prozac
Prozac might be widely prescribed to treat several issues related to the brain, but that does not mean it does not have its flaws.
Antidepressants in both adults and children have been seen to increase cases of suicidal thoughts and behavior. Close monitoring of patients needs to be carried out to ensure that the patients remain safe.
Depression is a known side effect of depression, but the chances according to multiple studies, increase when antidepressants enter the picture. Caregivers and families have to be warned about changes in behavior, agitation, irritability, and any other psychiatric and non-psychiatric indicators that may lead to fatal consequences.
Other more common side effects include drowsiness, nausea, anxiety, tiredness, loss of appetite, sweating, and dizziness.
Though it is important to remember if the doctor has prescribed this medicine, the benefits just might be outweighing the harm that those medicines would do to your body.
A doctor needs to be consulted immediately if any of the below side effects turn up sever mood swings, easy bruising, tremors, significant weight loss, decreased sex drive, and changes in sexual ability.
Cannabis is a Naturally occurring drug that comes from the Indian hemp plant called Cannabis sativa and Indica.
Cannabis is classified as a depressant drug. This does not mean that you become depressed if you take it, but rather your central nervous system slows down after you receive it.
Cannabis has two primary cannabinoids, cannabidiol (CBD) and tetrahydrocannabinol (THC).
Both cannabinoids interact with the endocannabinoid system, just in different ways.
THC gives a euphoric feeling to the user and is the reason behind the hallucinogenic effects, whereas CBD is the opposite. CBD binds with serotonin, the chemical responsible for our wellbeing and happiness, amongst other things.
Patients experiencing mental health conditions – from chronic pain to PTSD and depression- have been found to benefit from the administration of medical cannabis.
Research for marijuana and depression is in its preliminary stages. But even this research has been promising.
In one study, the researchers found that endocannabinoids found in cannabis may be helpful in treating depression that results from chronic stress. The study pointed out that chronic stress reduced the production of endocannabinoids. And this affects our cognition, emotion, and behavior.
Further links are being found between depression and the use of marijuana to manage the symptoms. Using compounds derived from cannabis could potentially help stabilize moods and ease depression.
Prozac and Marijuana
This is a complicated question to answer as multiple considerations need to be taken care of before you decide to start double dosing.
A significant issue with mixing the two is the emergence of a problem called hypomania. A mild form of mania, it is characterized by phases of elation and hyperactivity.
If you have any three of the below-mentioned symptoms, you are experiencing hypomania.
- Increased energy in the absence of sleep
- Always up for risky but pleasurable adventures
- Inability to stay focused and a distracted demeanor
- Talkative behavior
- Rapid thoughts
- Subjective Experiences
- Inflated ego or grandiosity regarding oneself
Hypomanic episodes do not require hospitalization. You can, on certain occasions, see a complete reversal of a person’s personality after hypomania. A person might become more friendly or outgoing after an episode.
In conclusion, it might not be deadly to mix the two, but there are always risks associated with having a cocktail of drugs, irrespective of what supposed research says. We would advise you to stick with one for maximum benefit and your safety. Consult a doctor before you go rogue on yourself.
Marijuana is not a miracle cure, but it can help you live a happier, more fulfilling life. Chat with us if you need assistance in getting a medical marijuana recommendation.
Is It Safe To Smoke Weed While On Prozac? As marijuana grows more accessible for patients suffering from depression and anxiety, it is expected that marijuana might have interactions with other