cirrhosis and marijuana

Marijuana May Protect the Liver from Alcohol — But Experts Urge Caution

Share on Pinterest Researchers are actively exploring cannabinoids that could be used to prevent or treat liver disease. Getty Images

The negative health consequences of misusing alcohol are becoming clearer every day.

Regularly exceeding the recommended daily limits of one drink for women and two drinks for men is associated with an increased risk for high blood pressure, stroke, and numerous cancers, including liver cancer.

Recently, researchers sought to understand the effects of regular alcohol and cannabis use on the liver.

While it may not be a good idea to combine intoxicating drugs, recent research finds that using alcohol and cannabis regularly has an unexpected effect on your health.

A 2018 study looked at about 320,000 people with a history of both misusing alcohol and using cannabis to discover what effect, if any, using both drugs had on liver health. What they found out was surprising.

Dr. Terence Bukong of the University of Massachusetts Medical School and the INRS-Institut Armand-Frappier Research Centre told Healthline: “The primary aim of our study was to assess the impact of cannabis use and the development of alcoholic liver disease.”

“Given that no clinical studies had previously evaluated the impact of cannabis use and the development of progressive stages of alcoholic liver disease in humans, we thought that this was an important research area which needed urgent investigation,” he added.

Dr. Hardeep Singh, gastroenterologist at St. Joseph Hospital in Orange, California, told Healthline, “Alcohol increases fibrosis in the liver, it has a direct toxic effect to liver cells and causes them to become inflamed. This causes scarring to the liver — advanced scarring of the liver is cirrhosis.”

He emphasized that the effect was very individual, with some people harmed by much lower alcohol intake than others.

But Bukong and team found that regular users of alcohol and marijuana significantly reduced the risk of alcoholic liver disease (ALD), and the heaviest cannabis consumers benefited the most.

The anti-inflammatory effects of cannabis are well-documented. Previous research had already found that cannabinoid receptors in the liver are potential targets for new ways to treat liver disease.

Activating these receptors with cannabis reduces the inflammation that happens early in ALD, slowing the progression of the disease.

However, Bukong cautioned, “Our studies could not ascertain which cannabis strains were used. So we couldn’t determine the cannabinoid content of what each individual ingested. We also couldn’t ascertain the dosage or modes of use, although it’s most likely through smoking.”

Singh emphasized, “However, some of this scarring goes away as the healthy liver regenerates, so cirrhosis can improve if an individual simply stops drinking. But, some scarring will remain.”

“My research group is currently working to discover which cannabinoids or cannabinoid formulations will provide the best therapeutic benefits for specific liver diseases,” Bukong said.

These anti-inflammatory properties are already being used to relieve pain, colitis (inflammation of the colon), multiple sclerosis, and arthritis.

“Our findings revealed that cannabis users were less likely to develop alcoholic liver disease, and cannabis-dependent individuals were the least likely individuals to develop alcoholic liver disease,” said Bukong.

He’s confident that “specific formulations of cannabinoids might soon be used [to] prevent or treat liver disease. My research group is actively working on important cannabis formulations which we hope will be important drug leads for future testing in the prevention and treatment of liver disease from inflammatory, metabolic, and even viral causes.”

Dr. Singh cautioned that one liver disease, hepatitis, is made worse by cannabis.

“Patients with hepatitis C who used cannabis had way more liver scarring than those who didn’t and more progression of their liver disease. Something in the cannabis could actually be increasing fatty liver disease and fibrosis,” he said.

Singh theorizes that some people have sensitivity to cannabis that influences whether they can benefit from it or not. “You can’t just tell the public marijuana is good for your liver, because there may also be people whose liver is harmed by it.”

He said current treatment, in limited cases, consists of “a short course of a steroid drug called prednisolone, for about eight weeks, which can help combat the effects of alcohol on the liver.”

He added that in some people with fatty liver disease, drinking two to three cups of black coffee per day has helped reverse scarring in the liver, although it’s not known which ingredient in coffee is providing the benefit.

According to National Institute on Alcohol Abuse and Alcoholism (NIAAA), drinking is responsible for roughly 88,000 deaths per year.

Could cannabis help reduce alcohol dependency to prevent liver disease?

A 2017 study looked at a clinical population of people with depression and alcohol use disorder (AUD) to find that marijuana had no beneficial effect, and could have worsened their depression.

The study concluded that — at least in people with depression — marijuana isn’t an effective treatment.

More evidence that cannabis won’t help wean people with AUD off alcohol is demonstrated in research that found that people treated for AUD, who also used marijuana, relapsed sooner than people who didn’t use marijuana.

There is strong evidence that stimulating the natural cannabinoid receptors in the liver can slow or even prevent the development of cancerous liver tumors. The health benefits associated with marijuana and cannabis products in general has created a lot of buzz.

Singh insists that, right now, too little is known about what effects cannabis compounds have on health.

“There are many substances in cannabis and it could be that one is really bad for the liver while another is beneficial. The take-home point is that more research is needed because we need data on both sides, good and bad,” he said.

The fact remains that cannabis is illegal in many parts of the United States and the world. It’s also important to remember that cannabis, like almost all drugs, is not harmless.

However, in a nod to the growing evidence that cannabis has medical benefit, the Food and Drug Administration (FDA) announced it will hold a public hearing May 31 to gather more information on the science, manufacturing, and sale of cannabis compounds.

Recent research finds that marijuana use is associated with a reduced risk of alcohol-related liver damage — including liver cancer.

However, there’s scant evidence that people who drink excessively can use marijuana to overcome a disorder. Research actually shows that it can worsen depression in some people with an alcohol use disorder.

As evidence grows that cannabis and cannabis-derived products can treat or prevent a broad range of health issues, it’s important to remember that marijuana is still illegal in many parts of the world.

Cannabis is a drug, and like any other drugs, has the potential to cause harm if misused.

A recent study shows that certain components in cannabis may help reduce inflammation associated with alcohol use and serious liver health issues.

Cannabis and Cirrhosis

  • Escrito por : Ciara
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Cannabis and cirrhosis are more linked than you’d think; cannabis is unveiling more properties and uses than ever, especially when it comes to receptors in our brain that act on our body. Today we’re going to talk about the CB2 receptor in relation with steatosis. Cirrhosis is a high risk factor that can be fatal and it’s been around for centuries, and it’s identified through alterations in tissue structure where nodes can appear or hepatic fibrosis. It tends to be due to circulation and blood pressure issues, which can be caused by a lacking diet or alcohol abuse.

We’ve already talked about CBD’s anti-inflammatory properties, although this particular cannabinoid doesn’t tend to directly stimulate the CB1 and CB2 receptors, rather it acts indirectly meaning that how it works is a bit of a mystery. It has a more direct effect on the 5-HT1A receptor, which has a pain relief effect, reducing pain signals that come from the receptors and increase alertness. CBD turns into Quinone in basic environments with oxygen, and in acidic environments with oxygen, CBD turns back into THC!

The CB2 receptor is related to the immune system, having been proven in various studies that if this receptor is stimulated, effects can be noticed in the liver, inhibiting inflammation caused due to alcohol use and steatosis (an accumulation of abnormal fat), stimulating Kupffer cells (macrophages in the liver that form sinusoidal walls). Apart from all of that, CBD also has antiprofibrotic properties that inhibit cell growth. This study was accompanied by experiments done on rats, which had their CB2 receptor inhibited and were given high quantities of ethanol; they began showing symptoms of steatosis and inflammation caused by alcohol. Once the theory had been confirmed, the rats’ CB2 receptors were stimulated using JWH-33 (a potent synthetic cannabin receptor stimulator) stimulating autophagy through hemo-oxygenase, an enzyme that limits the speed of the catabolism, reducing inflammation through lipopolysaccharides but not in all cells, those that have a deficiency of the ATG5 protein can’t be improved.

Hepatic encephalopathy is one of the final stages of cirrhosis, a manifestation of mental illnesses in patients that have this disorder. To study the issue more, rats were given thioacetamide, and their CB1 and CB2 receptors were stimulated, increasing neurological processes in the cognitive faculties, as well as regulating the brain’s kinase proteins, an enzyme that catalizes the production of phosphocreatine.

With this study it has been proven that CB2 is an efficient and powerful receptor, and when correctly stimulated it limits the progression of hepatic fibrosis and it inhibits any sort of inflammatory effects. This study, carried out by INSERM and the University of Paris, shows the link between stimulating the CB2 receptor and hepatic illnesses, underlining the anti-inflammatory effects and the hepato-protectors. During this study the effect of hemo-oxygenase was observed, a fundamental ingredient in getting rid of damaged cells. All of this should be considered quite an important step towards treating this illness using cannabinoids, and in fact cannabis users that suffer from chronic hepatitis C have proven to control the progression of hepatic fibrosis, confirming once again the amazing powers that this incredible plant has.

Author: Fabio Inga
Translation: Ciara Murphy

Cannabis and Cirrhosis: This amazing plant just won't stop surprising us with new uses and its incredible anti-inflammatory properties. ]]>